This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes.
Applications:
WB
Name of antibody:
TEK(Phospho-Tyr992)
Immunogen:
Peptide sequence around phosphorylation site of tyrosine 992 (E-V-Y(p)-V-K) derived from Human TIE2.
Full name:
TEK tyrosine kinase, endothelial
Synonyms:
TIE2; VMCM; TIE-2; VMCM1; CD202B
SwissProt:
Q02763
WB Predicted band size:
126 kDa
WB Positive control:
HepG2 cells lysates
WB Recommended dilution:
500-1000
相關文檔
Sample Application
Gel: 8%SDS-PAGE, Lysate: 30 μg, Lane 1-2: HepG2 cells lysates, lane2 is treated with the antigen-specific peptide , Primary antibody: D151317(TEK(Phospho-Tyr992) Antibody) at dilution 1/500 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute