This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED). [provided by RefSeq, Jun 2012]
Applications:
WB
Name of antibody:
AIRE(Phospho-Ser156)
Immunogen:
Peptide sequence around phosphorylation site of Serine156 P-G-S(p)-Q-L) derived from Human AIRE.
Full name:
autoimmune regulator
Synonyms:
APS1; APSI; PGA1; AIRE1; APECED
SwissProt:
O43918
WB Predicted band size:
58 kDa
WB Positive control:
Hela cells lysates treated with Hu
WB Recommended dilution:
500-1000
相關文檔
Sample Application
Gel: 10%SDS-PAGE, Lysate: 30 μg, Lane 1-2: Hela cells lysates treated with Hu, lane2 is treated with the antigen-specific peptide , Primary antibody: D151342(AIRE(Phospho-Ser156) Antibody) at dilution 1/500 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute