Order NO. D151716
兔抗FGFR1/2(Ab-463) 多克隆抗體
| 英文名 | Anti-FGFR1/2(Ab-463) rabbit polyclonal antibody | ||
| 別名 | PLC1; NCKAP3; PLC-II; PLC148; PLCgamma1/BEK; JWS; BBDS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM | ||
| 相關類別 | 一抗 | 儲存 | 冷凍（-20℃） 避光 |
| 宿主 | Rabbit | 反應種屬 | Human |
| 標記物 | Unconjugate | 克隆類型 | rabbit polyclonal |
| 抗原 | FGFR1/2(Ab-463) | ||
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| 編 號 | 包裝 | 庫存 | 目錄價（￥） | 您的價格（￥） | 數 量 |
| D151716-0025 | 25 ul | 現貨 |  |
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| D151716-0100 | 100 ul | 預計7日內發貨 | |
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| D151716-0200 | 200 ul | 預計7日內發貨 | |
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技術規格
| Background: | Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. |
| Applications: | WB |
| Name of antibody: | FGFR1/2(Ab-463) |
| Immunogen: | Synthesized peptide derived from Internal of human FGFR1/2. |
| Full name: | phospholipase C, gamma 1/fibroblast growth factor receptor 2 |
| Synonyms： | PLC1; NCKAP3; PLC-II; PLC148; PLCgamma1/BEK; JWS; BBDS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM |
| SwissProt: | P11362/P21802 |
| WB Predicted band size: | 92 kDa |
| WB Positive control: | Jurkat cells lysate |
| WB Recommended dilution: | 500-3000 |
相關文檔
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Sample Application
