Order NO. D194981
小鼠抗C9orf72單克隆抗體
| 英文名 | Anti-C9orf72 mouse monoclonal antibody | ||
| 別名 | C9orf72-SMCR8 complex subunit; ALSFTD; DENND9; FTDALS; DENNL72; FTDALS1 | ||
| 相關類別 | 一抗 | 儲存 | 冷凍（-20℃） |
| 宿主 | Mouse | 反應種屬 | Human, Mouse, Rat, Monkey |
| 標記物 | Unconjugate | 克隆類型 | mouse monoclonal |
| 抗原 | C9orf72 | ||
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| 編 號 | 包裝 | 庫存 | 目錄價（￥） | 您的價格（￥） | 數 量 |
| D194981-0100 | 100 ul | 預計5日內發貨 |  |
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技術規格
| Background: | The protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Studies suggest that hexanucleotide expansions could result in the selective stabilization of repeat-containing pre-mRNA, and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients (PMID: 23393093). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2016] |
| Applications: | WB, IHC, IF, FC |
| Name of antibody: | C9orf72 |
| Immunogen: | Fusion protein of human C9orf72 |
| Full name: | C9orf72-SMCR8 complex subunit |
| Synonyms: | ALSFTD; DENND9; FTDALS; DENNL72; FTDALS1 |
| SwissProt: | Q96LT7 |
| IHC positive control: | Human bladder cancer and Human breast cancer |
| IHC Recommend dilution: | 200-1000 |
| WB Predicted band size: | 54 kDa |
| WB Positive control: | C6, PC-12, COS-7, NIH/3T3 and SK-N-SH cell lysates |
| WB Recommended dilution: | 500-2000 |
| IF Positive control: | Hela cells |
| IF Recommended dilution: | 200-1000 |
| FC Recommended dilution: | 200-400 |
相關文檔
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Sample Application
