Order NO. D624518
CEP57抗原（重組蛋白）
| 英文名 | CEP57 Antigen (Recombinant Protein) | ||
| 別名 | MVA2; PIG8; TSP57 | ||
| 相關類別 | 抗原 | 儲存 | 冷凍（-20℃） |
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| 編 號 | 包裝 | 庫存 | 目錄價（￥） | 您的價格（￥） | 數 量 |
| D624518-0001 | 1 MG | 預計30日內發貨 |  |
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| D624518-0100 | 100 UG | 預計30日內發貨 | |
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產品描述
概述
Full length fusion protein
技術規格
| Full name: | centrosomal protein 57 |
| Synonyms: | MVA2; PIG8; TSP57 |
| Swissprot: | Q86XR8 |
| Gene Accession: | BC039711 |
| Purity: | >85%, as determined by Coomassie blue stained SDS-PAGE |
| Expression system: | Escherichia coli |
| Tags: | His tag C-Terminus, GST tag N-Terminus |
| Background: | This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. |
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